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    Fbxo10 F-box protein 10 [ Mus musculus (house mouse) ]

    Gene ID: 269529, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Fbxo10provided by MGI
    Official Full Name
    F-box protein 10provided by MGI
    Primary source
    MGI:MGI:2686937
    See related
    Ensembl:ENSMUSG00000048232 AllianceGenome:MGI:2686937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FBX10; Gm634
    Summary
    Predicted to be involved in protein ubiquitination; regulation of apoptotic process; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytoplasm. Orthologous to human FBXO10 (F-box protein 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 21.2), ovary adult (RPKM 16.4) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 B1; 4 23.68 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (45034248..45084555, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (45034248..45084604, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700055D18 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:45025246-45025433 Neighboring gene STARR-positive B cell enhancer ABC_E71 Neighboring gene STARR-seq mESC enhancer starr_10090 Neighboring gene zinc finger and BTB domain containing 5 Neighboring gene polymerase (RNA) I polypeptide E Neighboring gene predicted gene, 30939 Neighboring gene STARR-seq mESC enhancer starr_10091 Neighboring gene translocase of outer mitochondrial membrane 5 Neighboring gene FERM and PDZ domain containing 1 Neighboring gene FERM and PDZ domain containing 1, opposite strand

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice. Masle-Farquhar E, et al. PLoS One, 2021. PMID 33914737, Free PMC Article
    2. Signaling complexes of the FERM domain-containing protein GRSP1 bound to ARF exchange factor GRP1. Klarlund JK, et al. J Biol Chem, 2001 Oct 26. PMID 11445584
    3. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice.
      Title: Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (6)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box only protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024142.2 → NP_001019313.1  F-box only protein 10 isoform 2

      See identical proteins and their annotated locations for NP_001019313.1

      Status: VALIDATED

      Source sequence(s)
      AL824706
      Consensus CDS
      CCDS51171.1
      UniProtKB/Swiss-Prot
      A2ANI6, Q6AXG0, Q7TQF2, Q7TQM0
      UniProtKB/TrEMBL
      Q505G2
      Related
      ENSMUSP00000058233.7, ENSMUST00000052236.13
      Conserved Domains (2) summary
      pfam12937
      Location:6 → 50
      F-box-like; F-box-like
      pfam13229
      Location:460 → 606
      Beta_helix; Right handed beta helix region

    2. NM_001378819.1 → NP_001365748.1  F-box only protein 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL824706
      Conserved Domains (2) summary
      pfam12937
      Location:6 → 49
      F-box-like
      pfam13229
      Location:460 → 616
      Beta_helix; Right handed beta helix region

    3. NM_001378820.1 → NP_001365749.1  F-box only protein 10 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL824706
      Conserved Domains (1) summary
      pfam13229
      Location:273 → 419
      Beta_helix; Right handed beta helix region

    4. NM_001378821.1 → NP_001365750.1  F-box only protein 10 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL824706
      Conserved Domains (2) summary
      pfam12937
      Location:6 → 49
      F-box-like
      pfam13229
      Location:460 → 606
      Beta_helix; Right handed beta helix region

    5. NM_001378822.1 → NP_001365751.1  F-box only protein 10 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL824706
      Conserved Domains (2) summary
      pfam12937
      Location:6 → 49
      F-box-like
      pfam13229
      Location:460 → 616
      Beta_helix; Right handed beta helix region

    6. NM_001378823.1 → NP_001365752.1  F-box only protein 10 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL824706
      UniProtKB/TrEMBL
      Q505G2
      Related
      ENSMUSP00000119862.2, ENSMUST00000140008.2
      Conserved Domains (1) summary
      pfam13229
      Location:273 → 419
      Beta_helix; Right handed beta helix region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      45034248..45084555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TQF2.2 GenPept UniProtKB/Swiss-Prot:Q7TQF2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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